Unspecified insomnia icd 1012/11/2023 ![]() Details of the methodology have been published previously (Rathmann et al. This study used data from German primary care practices from the DA database (IQVIA). Given the limited data available to date, this study aims to investigate this association specifically for gastrointestinal (GI) cancer using a large real-world cohort from Germany based on the IQVIA Disease Analyzer (DA) database. However, the relationship between different sleep disorders and specific cancer site is not very clear and appears to be bidirectional (Mogavero et al. 2015), and colorectal cancer (Stevens et al. In this context, several studies have suggested an increased risk of several cancer types including breast cancer (Davis et al. In recent years, there has even been growing evidence of an association between sleep and cancer (Büttner-Teleagă et al. Other studies have linked sleep disorders to the risk of infectious and inflammatory diseases and all-cause mortality (Kripke et al. found that disrupted sleep was also a risk factor for subsequent depression, with twice the risk compared with undisturbed sleep (Baglioni et al. Additionally, sleep disorders have been associated with weight gain and an increased risk of developing diabetes or metabolic syndrome (Patel et al. 2021), as well as stroke (Bassetti 2005). As such, sleep disorders have been discussed as an independent risk factor for myocardial infarction, heart failure and hypertension (Laugsand et al. Indeed, sleep disorders have been reported to be associated with a wide range of physical and mental health problems (Schlack et al. Sleep is known to be important for human health (Schlack et al. Obstructive sleep apnea (OSA), on the other hand, is defined by episodes of complete or partial airway collapse associated with decreased oxygen saturation or arousal from sleep (Slowik et al. Insomnia is characterized by delayed sleep onset, impaired sleep maintenance, reduced total sleep time, and/or early morning awakening (Sutton 2021). ![]() Of these, insomnia and obstructive sleep apnea (OSA) have an estimated prevalence of 6–20% and 9–38%, respectively, in the general population (Riemann et al. Sleep disorders are one of the most common health problems in the general population and result in significant socioeconomic and healthcare costs (Lateef et al. Our findings suggest that sleep disorders might be indicative of short-term health outcomes, including GI cancer, suggesting a role for sleep disorder screening in the context of cancer prevention efforts. Stratified analyses by cancer site revealed higher odds of sleep disorders prior to diagnosis of gastric, pancreatic, and colorectal cancer. No association with cancer was found for sleep disorders in the overall history before the index date (OR 1.04 95% CI 0.96–1.12), but considering sleep disorders documented within 1 year before the index date showed a positive association with GI cancer overall (OR 1.20 95% CI 1.08–1.34). ResultsĪfter matching, 37,161 cases with GI cancer and 37,161 controls without cancer were available for analysis. To determine whether sleep disorders were more common in patients with GI cancer than in patients without GI cancer, logistic regression models were used to estimate odds ratios (ORs) with 95% confidence intervals (95% CI). The outcome of the study was the association between sleep disorders and subsequent diagnosis of GI cancer. Using the DA database (IQVIA), adult patients diagnosed with GI cancer between January 2010 and December 2022 were retrospectively compared to a 1:1 propensity score-matched cohort of patients without cancer. We aimed to investigate this association specifically for cancers of the gastrointestinal (GI) tract. ![]() Recently, there has been increasing evidence of an association between sleep disorders and cancer risk. Sleep disorders are among the most common health problems worldwide and are linked to a variety of physical and mental health problems.
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